Read the latest news from our vision science laboratories and related clinical matters.
Research supported by Gift of Sight is undertaken in the University of Southampton and informed by conditions seen in patients in Southampton Eye Unit.
The University of Southampton has made it possible for us all to work from home in these challenging times. Please be assured that our office is 'business as usual'. The telephone in the Gift of Sight office will forward calls to our mobile phone. If we don't reply immediately please leave a message and we'll get back to you.
Delighted to advise that the laboratories are up and running again, although in 'shifts' to protect our wonderful research team.
Please read our latest Newsletter
28 July 2020 Congratulations to Dr Arjuna Ratnayaka who has been awarded £100,000 from the UK Macular Society @MacularSociety to recruit a PhD student to study how pathogenic macromolecules aggregate inside retinal pigment epithelial (RPE) cells in the eye. These high-molecular-weight compounds cause cellular dysfunction, resulting in eventual atrophy of RPE cells associated with irreplaceable loss of overlying photoreceptors.
The PhD studentship, which will commence in the autumn, will study how these toxic macromolecules form, and whether boosting the cells’ proteolytic response can prevent RPE damage. Potential findings from this study could pave the way for developing new treatments for common blinding conditions such as age-related macular disease (AMD) as well as some rare retinal dystrophies.
24 July 2020 Sharing the latest Clinical Research Wessed (CRN) newletter. Dan Osborne, one of our Research Orthoptists has shared details of his project studying children with amblyopia (lazy eye). He and Jay Self are hoping to encourage a 'testing at home' for these children to save numerous visits to clinic and time off work for parents and carers.
20 July 2020 Paper published regarding study into Sorsby Fundus Dystrophy., a rare autosomal dominant disease of the macula. Congratulations to our vision science team, colleagues in Finland and Dr Jenny Dewing in particular who has really brought this project forward.
03 June 2020 Worldwide open access to Publication of Management of nystagmus in children: a review of the literature and current practice in UK specialist services paper. PubMed
24 January 2020 Paper published in The Lancet reflecting results of a trial into Central Serous Chorioretinopathy. Shared on Youtube too.Eplerenone has been used to treat patients but has side effects for some. After completion of the VICI study it is recommended that the drug is no longer prescribed for this condition as there are no benefits to be seen.
26 December 2019 Publication of a paper in PubMed detailing how children with nystagmus get very variable support and information currently in the UK. Jay Self and his team are keen to standardise the management and care for these children in a series of papers aimed to highlight the problem.
13 August 2019 Congratulations to Dan Osborne, who works as a research orthoptist in the paediatric clinic in Southampton Eye Unit, on being awarded a HEE/NIHR Pre-doctoral Clinical Academic Fellowship 2019. Dan is the first orthoptist to receive this funding. He was also the winner of the first Gift of Sight Clinical Award and we'll look forward to following his career.
4 June 2019 Amazing new procedure for corneal transplants reported by Professor Parwez Hossain. Link to press release here.
28 March 2019 Congratulations to our team on the publication of a paper linking an unhealthy diet with eye disease.
19 March 2019 : Our amazing team trekking Kilimanjaro for children's eye research have raised the magnificent sum of £21,500. Please read their story on their JustGiving page.
A new video from Dr Helena Lee, Associate Professor of Opthalmology.
Helena Lee was recently a speaker at a hugely successful new TED-style event, AMSlive, organised by The Academy of Medical Sciences. We are delighted to share her talk here.
Research funding for study into early stage age-related macular degeneration (AMD)
Professor Andrew Lotery has been successful grant application to the Wellcome Trust
The five-year research project will teach computers to analyse high resolution images of the inside of the eye to identify what eye changes appear in patients with AMD and identify the structural changes that lead to and are associated with cell degeneration in the retina in patients with early AMD.
A recent press release which can be viewed here gives details of a clinical trial which will be taking place in Southampton in due course.
Stargardt’s disease, also known as Stargardt‘s macular dystrophy, affects the area of the retina called the macula and causes a reduction in central vision.
It is the most common form of juvenile macular degeneration and affects around one in 10,000 children who suffer a gradual decline in vision which leads to blindness in adulthood. The press release gives full details.
The study has been funded by the European Union. However there are still many additional steps to be taken before the study begins. These steps include completion of the study protocol and obtaining ethics approval. To ensure the best possible outcome from the study all of these steps take time and therefore the project is unlikely to start until the end of 2018 or possibly in 2019, once the protocol has been finalised on who might be eligible for the study.
If you would like to register your interest in this project please send an email to EyeResearch@uhs.nhs.uk
Albinism and Age-related macular degeneration
Mr Jay Self (Consultant Ophthalmologist) and members of the vision research team are interested in discovering why, to their knowledge, Albinism and Age-related macular degeneration (AMD) have never been seen in the same patient, although AMD affects 1/3 of people over the age of 75.
Also the retina loses function in older animals with Albinism but, apparently, not in humans.
If anyone reading this post is aged over 60 and has Albinism, please contact Jay by email at J.E.Self@soton.ac.uk . If you know anyone who meets this criteria please do share our message with them and ask them to make contact with Jay. Thank you.
Congratulations to Mr Parwez Hossain
on being part of a team who won an award for participation in an interfaculty collaboration within the University of Southampton’s Network for AntiMicrobial Resistance & Infection Prevention (NAMRIP). The participants are from Electronic Engineering; Molecular Microbiology; Ophthalmology (Eye Unit) and Southampton University NHS Hospital Trust. It has produced a flourishing collaboration with Lighthouse in Kenya, and with the Christian Medical College (Vellore, India). The collaboration has developed a novel portable device, using the application of a technology known as electrical impedance, to identify different types of bacteria with no sample preparation and ‘instant’ detection from, literally, a drop of specimen.
Professor Andrew Lotery - press release 19 April 2017
Congratulations to Professor Andrew Lotery and everyone in the clinical research teams
on being selected as runners up for 'research team of the year' by University Hospital Southampton NHS Foundation Trust Hospital Heroes Awards.
Professor Lotery also won the 'Clinical impact through research' award for delivering a research study which has led to a change in clinical practice locally. 27.03.17.
Patients who attend Southampton Eye Unit are drawn from the whole of Hampshire and community support is very much appreciated.
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If you would like to become involved or simply want to find out more please make contact firstname.lastname@example.org or telephone Ailsa Walter on 02380 599073.